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5’-GpG islands of p15 gene hypermethlation in non-Hodgkin’s lymphomas |
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| Authors: | ZHOU Tao FAN Hong-tao ZHANG Ning LIU Xing-jing HU Bao-chun GUO Qiu-ye GUO Xiu-zhi |
| Institution: | 1.Department of Oncology, Guangdong Provincial Corps Hospital of Chinese People’s Armed Forces, Guangzhou 510507, China;2.Laboratory of Population Genetics, NIH/NCI/LPG， USA;3.Institute of Gene Research, Southern Medical University, Guangzhou 510515, China;4.Institute of Hematology, Medical College of Jinan University, Guangzhou 510632, China |
| Abstract: | AIM:To illustrate the expression of hypermethylation p15 gene in 53 non-Hodgkin’s lymphoma (NHL). METHODS:The methylation of p15 gene in 53 cases of non-Hodgkin’s lymphoma was detected by using methylation-specific PCR (MSP) technique. RESULTS:18.9% (10/53) in NHL were methylation in p15 gene. p15 gene was frequently in high malignant NHL patients (27.3%) compared with in low malignant patients (0%). CONCLUSION:The result suggested that the hypermethylation of p15 may play an important role in non-Hodgkin’s lymphoma. |
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