The coordinated regulation between nuclear DNA and mitochondria DNA |
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| Authors: | CHEN Li-feng LIU Jun-ze |
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| Affiliation: | Department of Pathophysiology, Institute of High Altitude Military Medicine, The Third Military Medical University, Chongqing 400038, China |
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| Abstract: | The overall cellular gene expression is well realized by the coordinated regulation between nuclear DNA and mitochondria DNA. Coordinated regulation between two genomes plays a key role not only in mitochondria biogenesis and protein synthesis but also more importantly in the regulation of gene expression of mitochondria respiratory chain subunits in order to mediate the mitochondrial respiratory function. In the present review, we focus on the mechanism of coordinated regulation between two genomes. |
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