Effect of Shenfu injection on hemodynamics of hypovolemic shock and oxygen delivery

AIM: To evaluate the effect of Shenfu injection on hemodynamics of hypovolemic shock patients and oxygen delivery by transesophageal Doppler echocardiography (Hemosonic 100 TM). METHODS: The transesophageal probe was placed in 32 patients with hypovolemic shock. 50 mL Shenfu injection were intravenously administered within 5 min. The parameters, including ABF, SVa, Acc, LVETi and TSVRa, were recorded at interval of 5, 10, 20, 30, 60 and 120 min. Meanwhile, MAP was measured at the same interval. Arterial and venous blood gases were taken at the beginning and 30, 60 and 120 min of the trial. DO2, VO2 and ERO2 were calculated. RESULTS: Acc, SVa, ABF increased while TSVRa decreased at 10 min after administration of Shenfu injection (P<0.01). DO2 and VO2 increased (P<0.01) and ERO2 decreased (P<0.05). CONCLUSION: Shenfu injection has a beneficial effect on hypovolemic shock by increasing cardiac output and improving oxygen delivery.