Inhibitory effects of genistein on mouse allergic contact dermatitis |
| |
| Authors: | CONG Lin ZENG Yao-ying CAI Xiao-chang YI Min SHI Jun |
| |
| Institution: | 1.Department of Dermatology, The First Affiliated Hospital, 2 Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, China |
| |
| Abstract: | AIM: To investigate the inhibitory effects of genistein (Gen) on mouse allergic contact dermatitis (ACD). METHODS: The animal model of ACD was induced by DNFB. The effects of different doses of Gen on mouse ear swelling，body weight, histopathological changes in mouse ear skin, thymus index and spleen index were observed. RESULTS: All groups of Gen inhibited mouse ear swelling induced by DNFB significantly. The infiltration of inflammatory cells and thymus index were also reduced. However, the increase in mouse body weight was not affected. Low dose of Gen increased spleen index, high dose of Gen decreased spleen index. CONCLUSION: Genistein has significant inhibitory effects on mouse ACD induced by DNFB. |
| |
| Keywords: | |
|
| 点击此处可从《园艺学报》浏览原始摘要信息 |
| 点击此处可从《园艺学报》下载免费的PDF全文 |
|
