Architecture of FcαR1 gene in Chinese Han population in Guangdong province

AIM：To construct the SNP haplotypes and the haplotype blocks of FcαR1 gene in Chinese Han population in Guangdong province.METHODS：Genomic DNA was extracted from 100 healthy Chinese Han subjects.Genotypes of the SNPs in FcαR1 gene were determined by PCR and direct sequencing.Constructing the SNP haplotypes and the haplotype blocks of FcαR1 gene by 12 SNPs that is its minor allele frequency were more than 0.1 with Haploview soft.RESULTS：There are 3 haplotype blocks in FcαR1 gene in Chinese Han population in Guangdong province.The number of haplotypes in each haplotype blocks was from 3 to 7 (average 5.33).However,the number of common haplotypes in each blocks was from 2 to 3 (average 2.3).CONCLUSION：Our results show the existence of the block-like structures and the common haplotypes in each block in FcαR1 gene.It provides a useful tool for the genome research and the mapping of disease contributing genes/variants in this gene.