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Effect of H2O2 on voltage-gated potassium channels in rat pulmonary artery smooth muscle cells |
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| Authors: | LUO Hong-yan TANG Ming DU Yi-mei LIU Chang-jin TANG Bi HU Xin-wu HU Mou-xian XI Jiao-ya SONG Yuan-long Jurgen Hescheler |
| Institution: | 1.Department of Physiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China. E-mail:tangming49@hotmail.com;2.Institute of Neurophysiology, University of Cologne, D-50931 Cologne, Germany |
| Abstract: | AIM:To determine the effect of hydrogen peroxide (H2O2) on voltage-gated potassium channel currents (IKv) in pulmonary vascular smooth muscle cells (PASMCs). METHODS:Using whole cell patch-clamp technique, IKv was recorded in freshly isolated rat PASMCs with acute enzymatic digestion method. The effect of hydrogen peroxide on IKv in PASMCs was investigated in normoxia. RESULTS:IKv in PASMCs was increased significantly by H2O2 and the increase depended on the concentration in normoxia. Current-voltage relationship curve shifted to the left. CONCLUSION:Hydrogen peroxide is an important K+ channel opener. |
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