一例犬前肢血管周细胞瘤的病理及免疫组化分析

血管周细胞瘤是一种软组织肉瘤,起源于毛细血管壁的周细胞。在本报道中,描述了一只11岁中华田园犬的左腿腕关节肿块。为确定肿块性质,采用影像学、细胞学和病理学检查加以诊断。X光检查显示肿瘤始于软组织,肿物界限清晰;细胞学检查显示细胞呈梭形,核仁明显,细胞核大小不一;病理组织学结果显示存在围绕血管的梭形细胞;免疫组织化学结果显示波形蛋白和α-SMA阳性表达,desmin和S-100阴性表达,肿瘤组织中PCNA阳性肿瘤细胞的数量大于25%,Masson trichrome染色显示肿瘤组织中胶原纤维的含量少。结合病理学及免疫组化确诊为血管周细胞瘤。

Pathological and Immunohistochemical Analysis of Hemangiopericytoma in a Dog Forelimb

Hemangiopericytoma is a soft tissue sarcoma that originate from the pericytes of the capillary wall. In this study, we described a left radiocarpal joint mass in an 11-year-old female mixed-breed dog. Iconography, cytology, histopathology, and immunohistology were used to determine the nature of the mass. X-ray imaging showed that the tumor began in soft tissue and had clear boundaries; cytology showed that the cells were spindle-shaped, with obvious nucleoli and variably sized nuclei; histopathology revealed the presence of spindle cells surrounding blood vessels; immunohistochemistry was positive for vimentin and α-SMA, and negative for desmin and S-100. The number of PCNA positive tumor cells was more than 25%. Masson trichrome staining showed that the content of collagen fibers in tumor tissue was low. The diagnosis of hemangiopericytoma was confirmed by pathology and immunohistochemistry.