中草药对断奶仔猪生长性能影响的Meta分析

利用Meta分析方法对已发表的中草药在断奶仔猪阶段应用试验研究进行评价，为断奶仔猪保健治疗提供参考。通过计算机检索CNKI、Wanfang Data、Science Direct、Web of Science、VIP数据库，全面收集中草药在断奶仔猪阶段添加的对照试验。采用Cochrane协作网推荐的Review Manager 5.3软件对各效应指标进行Meta分析。共纳入27篇文献，1 870头仔猪，试验组935头，对照组935头，试验组均采用中药治疗，对照组采用金霉素、硫酸黏杆菌素、硫酸黏杆菌素+杆菌肽锌等抗生素治疗。结果显示：中药组对日增重的影响优于整体抗生素组SMD=1.22，95% CI（0.69~1.75），P<0.01]，但与金霉素组统计学无差异（P>0.05）；中药组日采食量优于整体抗生素组SMD=0.77，95% CI（0.34~1.20），P<0.01]，但与金霉素组作用相当（P=0.05）；中药组和抗生素组的料重比差异不显著SMD=-0.35，95% CI（-0.78~0.09），P=0.12>0.05]，但显著优于硫酸黏杆菌素和金霉素亚组（P<0.01）；中药组的腹泻率极显著低于抗生素组{SMD=-1.77，95% CI-2.52~（-1.01）]，P<0.01}，但与硫酸黏杆菌素+杆菌肽锌组相比，效果相当（P>0.05）。仔猪断奶阶段添加中草药，在日增重、日采食量、腹泻率指标上优于抗生素组，即中药在断奶仔猪阶段研究具有重要潜力。

Effect of Chinese Herbal Medicine on the Growth Performance of Weaned Piglets by Meta-analysis

The published clinical trial about treatment of weaned piglet stage with Chinese herbal medicine were systemically evaluated by meta-analysis method, in order to provide valuable reference for treatment of weaning piglet health care. The clinical randomised controlled trials (RCTs) about treatment were searched completely from databases of Science Direct, Web of Science, CNKI, Wanfang Database, VIP Database, etc, using the Review Manager 5.3 software recommended by the Cochrane Collaboration. A total of 27 RCTs and 1 870 weaned piglets were included, among them, 935 weaned piglets in treatment group treated with Chinese herbal medicine, 935 weaned piglets in control group treated with chlortetracycline, colistin sulfate, colistin sulfate + bacitracin zinc. Results showed that:the daily weight gain effect of Chinese medicine group was better than the overall antibiotic groupSMD=1.22, 95%CI(0.69-1.75), P<0.01], but there is no difference with the chlortetracycline group(P>0.05). The daily feed intake of Chinese medicine group was better than the overall antibiotic groupSMD=0.77, 95%CI (0.34-1.20), P<0.01], but equivalent to the chlortetracycline group (P=0.05).The difference in Feed weight ratio between the Chinese medicine group and the antibiotic group was not significantSMD=-0.35, 95%CI(-0.78-0.09), P=0.12>0.05], However, it was significantly better than the colistin sulfate and chlortetracycline subgroup (P<0.01).The effect of Chinese medicine on diarrhea rate was significantly lower than antibiotics{SMD=-1.77, 95%CI-2.52-(-1.01)], P<0.01}, However, the effect was comparable to that of the colistin sulfate + bacitracin group (P>0.05). The Chinese herbal medicine was added at the weaning stage of the piglets. The indexes of daily gain, daily feed intake and diarrhea rate were superior to that of the antibiotic group, that is, the traditional Chinese medicine has the potential of traditional Chinese medicine in the stage of weaning piglets.