| 细菌双组分系统的研究进展 |
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| 引用本文： | 郝艳华,张维,陈明.细菌双组分系统的研究进展[J].中国农业科技导报,2012,14(2):67-72. |
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| 作者姓名： | 郝艳华 张维 陈明 |
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| 作者单位： | (中国农业科学院生物技术研究所, 北京 100081) |
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| 基金项目： | 国家自然科学基金项目(30970069);戈壁沙漠核辐射区微生物适应进化及生物多样性研究项目(31170105);国家转基因生物新品种培育重大专项(2011ZX08012-001)资助 |
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| 摘 要： | 细菌需要复杂而精密的信号系统来应对体内外环境变化,从而适应环境并得以生存。双组分系统（two component system, TCS）广泛存在于原核生物细胞中,由组氨酸激酶（histidine kinase,HK）和反应调控蛋白（response regulator,RR）组成,通过双组分蛋白的磷酸化和去磷酸化调节细胞信号传导途径。介绍了双组分系统的结构、反应机制和功能等方面研究进展,并探讨了双组分系统在细胞信号传导中的作用。
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| 关 键 词： | 细菌 双组分系统 信号转导 交叉调节 |
Research Progress on Two Component System of Bacteria |
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| HAO Yan-hua
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ZHANG Wei
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CHEN Ming.Research Progress on Two Component System of Bacteria[J].Journal of Agricultural Science and Technology,2012,14(2):67-72. |
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| Authors: | HAO Yan-hua ZHANG Wei CHEN Ming |
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| Institution: | (Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China) |
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| Abstract: | Bacteria needs complex and accurate signal transduction system to adapt to the changes in cellular and environment.Two component systems are abundant in prokaryotes,which consist of a histidine kinase(HK) and a response regulator(RR).They regulate cellular signal transduction pathway,according to phosphorylation and dephosphorylation.This review mainly introduces the progress made in structure,mechanism and function research,and explores the role of two component systems in cell signal transduction. |
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| Keywords: | bacteria two component system signal transduction cross adjustment |
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