Expression of SARS-CoV functional receptor angiotensin-converting enzyme 2 in nephritic epithelium of primates |
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| Authors: | YANG Xiu-hong QIN Chuan△ CHEN Yun-xin ZHU Hua HUANG Lan LIU Ya-li MA Chun-mei ZHANG Lian-yuan YANG Fang |
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| Affiliation: | 1.Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences and Peking ;Union Medical College, Beijing 100021, China;2.Department of Physiology, North Coal Medical University, Tangshan 063000, China. E-mail: qinchuan@pumc.edu.cn |
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| Abstract: | ![]()
AIM: To investigate the expression of angiotensin-converting enzyme 2 (ACE2) in nephritic epithelium of primates. METHODS: The expression of ACE2 in Vero E6 cells was detected by the techniques of RT-PCR and immunocytochemistry (ICC) techniques. The distribution of ACE2 protein in kidney tissues of two Rhesus monkeys and two normal human cases was observed by immunohistochemistry (IHC) techniques. RESULTS: Vero E6 cells were found to express both ACE2 mRNA and protein. ACE2 protein was mainly located in epithelium of proximal tubules of Rhesus monkey and human kidney. CONCLUSION: The expression of ACE2 in epithelium of primate kidney may provide the condition for SARS-CoV entry, which may be one of the reasons for inducing renal damage in SARS patients. |
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