壳聚糖铜对断奶仔猪生产性能、肠道菌群及黏膜形态的影响

 【目的】研究壳聚糖铜对断奶仔猪生产性能、肠道菌群和肠道黏膜形态等方面的影响,为壳聚糖铜的利用提供科学依据。【方法】选择120头体重(7.8 ± 0.2 kg)的“杜长大”三元杂交断奶仔猪随机分为4组。分别饲喂4种日粮：基础日粮组不添加外源铜(对照组),其它组在基础日粮基础上分别添加50、100 mg?kg-1壳聚糖铜(CS-Cu)、200 mg?kg-1硫酸铜,预饲期7 d,试验期30 d。【结果】50、100 mg?kg-1 CS-Cu和200 mg?kg-1硫酸铜组的日增重分别比对照组显著增加(P＜0.05),料重比显著降低(P＜0.05);添加CS-Cu可使盲肠和结肠内容物中大肠杆菌、沙门氏菌数量明显降低(P＜0.05),而乳酸杆菌数量显著升高(P＜0.05);与硫酸铜组相比, 100 mg?kg-1 CS-Cu组空肠和回肠隐窝深度显著降低(P＜0.05);空肠绒毛高度明显提高(P＜0.05)。【结论】日粮中添加100 mg?kg-1CS-Cu与200 mg?kg-1硫酸铜,对提高断奶仔猪日增重和降低料重比具有等同的效果;日粮中添加CS-Cu具有改善肠道微生态平衡和肠道形态的作用。

Effects of Chitosan-Copper on Growth Performance and Intestinal Flora and Its Morphology in Weanling Piglets

【Objective】 The study was conducted to observe the effects of chitosan-copper(CS-Cu) on growth performance, intestinal flora and its morphology of piglets. 【Method】 One hundred and twenty Duroc×Landraee×Yorkshire piglets (average BW of 7.8 ± 0.2 kg) were randomly divided into 4 treatment groups and fed with basic diet or basic diet supplemented with 50 mg?kg-1 CS-Cu, 100 mg/kg CS-Cu and 200 mg?kg-1 CuSO4, respectively. The experiment lasted 30 days.【Result】 The average daily gain (ADG) of the CS-Cu groups and 200 mg?kg-1 CuSO4 group significantly increased (P＜0.05) and the feed gain ratio (F/G) significantly decreased (P＜0.05) comparing with the control group. The salmonella population and E. coli population in CS-Cu groups were lower than those of the control group (P＜0.05), and lactobacillus population was higher than that of the control group (P＜0.05). And the 100 mg?kg-1 CS-Cu group had an obvious increase in the jejunal villous height(P＜0.05) and a significant reduction in the intestine erypt depth(P＜0.05) compared with the 200 mg?kg-1 CuSO4 group. 【Conclusion】 The results indicated that efficiency of 100 mg?kg-1 CS-Cu group was similar as 200 mg?kg-1 CuSO4 group, the addition of CS-Cu could modulate the micro-ecology balance and improve the intestinal morphology. And the diarrhea rate of the CS-Cu groups was obviously lower than that of the CuSO4 group.