体外培养细胞端粒酶活性调控的研究进展

端粒酶可修复细胞分裂过程中不断丢失的端粒序列,从而维持端粒的长度,在动物细胞寿命的调控中起着很重要的作用。因此,通过调控细胞中端粒酶的活性来影响体外培养细胞的发育状况,是目前提高体外培养效率的有效方法之一。文章对调节细胞中端粒酶活性的研究进展作一综述。

Advances of Telomerase Activation Regulation in Cells Cultured in Vitro

Telomerase is capable of maintaining telomere lengths by balancing out the gradual loss of telomeric sequences that occurs during cell division.It plays an important role in regulating life span of animal cells.In order to improve cell culture efficiency in vitro,a great deal of research has been attempted.And the way of increasing the activity of telomerase is considered to be one of the most effective approaches to improve cell culture efficiency.This article will make a brief summary of these recent achievements.