病毒性肝炎患者血清微量元素的检测及其临床意义

目的:探讨病毒性肝炎患者和肝炎肝硬化患者血清微量元素水平与病情的相关性。方法:采用RI- 10 0 0 TM全自动生化分析仪检测2 73例病毒性肝炎患者(慢性肝炎130例、急性肝炎35例、重型肝炎38例、肝炎肝硬化70例)及4 0例正常对照者血清中镁、铁、铜、锌的水平。结果:各型肝炎及肝硬化患者血清锌水平均显著低于正常对照组(P<0 .0 1)。除急性肝炎组外,慢性肝炎、重型肝炎、肝炎肝硬化患者血清中镁、铜水平均显著低于正常对照组(P<0 .0 1) ,血清中镁、铜、锌水平以重型肝炎组最低。各型肝炎及肝硬化患者血清铁水平均显著高于正常对照(P<0 .0 1) ,以重型肝炎组最高。结论:检测病毒性肝炎患者血清中的微量元素,对了解病情及指导临床治疗具有一定的意义。

Serum levels of trace elements in patients with viral hepatitis

Objective: To investigate the relationship between serum levels of trace elements and severity in patients with viral hepatitis. Methods: Serum levels of magnesium, iron, copper and zinc were determined by RI-1000 TM biochemical analysator in 273 patients with viral hepatitis including 35 acute hepatitis, 130 chronic hepatitis, 38 fulminant hepatitis and 70 posthepatitic cirrhosis, and 40 normal subjects. Results: Compared with the controls, zinc levels decreased and iron contents increased in hepatitis and cirrhosis (P<0.01). Levels of magnesium and copper were obviously lower in hepatitis except acute hepatitis than those in controls (P<0.01), especially in fulminant hepatitis. Conclusion: Serum microelement detection in patients with viral hepatitis is helpful in the severity judgment and regimen design.