Antibody seroprevalences against rabies in dogs vaccinated under field conditions in Bolivia |
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Authors: | K Suzuki M R Pecoraro A Loza M Pérez G Ruiz G Ascarrunz L Rojas A I Estevez J A Guzman J A C Pereira E T González |
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Institution: | (1) Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Av. 60 y 118, La Plata, B1900AVW Buenos Aires, Argentina;(2) Facultad de Ciencias Veterinarias, Universidad Autónoma Gabriel René Moreno, Av. 26 de Febrero entre Av. Busch y Centenario, Santa Cruz de la Sierra, Bolivia;(3) Laboratorio de Investigación y Diagnóstico Veterinario, Av. Ejercito N° 153 y Casilla N° 29, Santa Cruz de la Sierra, Bolivia |
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Abstract: | Bolivia currently has one of the highest numbers of cases for human and canine rabies and is thus clue to the elimination
process. The objective of the present study was to assess antibody seroprevalences against rabies in dogs vaccinated under
field conditions and other factors that might influence the success of the on-going rabies control programmes in an endemic
area of the disease, Santa Cruz de la Sierra, Bolivia. All 240 study animals, selected using area-stratified random sampling,
were investigated in April 2007. Test prevalences were adjusted for the imperfect test characteristics using the Rogan–Gladen
estimator (deterministic and stochastic functions) and Bayesian inference. Ninety-four of the tested 240 vaccinated dogs were
classified as test-positive for rabies-specific antibodies. With regard to adjusted overall antibody seroprevalence, Bayesian
true prevalence estimates (41%, 95% CI: 37–46%) were lower than both of the Rogan–Gladen estimates. The effect of various
epidemiological factors on post-vaccination response was also assessed. |
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Keywords: | ELISA Field investigation Immune response South America True prevalence estimation |
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