| 大黄有效期的研究 |
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| 引用本文： | 杨磊,朱青,张志国,曹臣.大黄有效期的研究[J].安徽农业科学,2012(36):17534-17535,17537. |
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| 作者姓名： | 杨磊 朱青 张志国 曹臣 |
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| 作者单位： | 湖南中医药大学第一附属医院,湖南长沙,410007;湖南省肿瘤医院,湖南长沙,410013 |
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| 基金项目： | 湖南省自然科学基金项目(编号:10JJ5018) |
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| 摘 要： | 目的]对中药材大黄的有效期进行研究.方法]选用易氧化变色的大黄,通过经典恒温试验,采用HPLC测定大黄酸、大黄素、大黄素甲醚、芦荟大黄素的含量,并研究该药有效成分含量的变化规律.结果]经典恒温法测定的大黄酸、大黄素、大黄素甲醚、芦荟大黄素含量变化符合一级反应规律.在20℃的储藏条件下,大黄有效成分的含量变化速度常数为K=1.585×10-5,该批大黄有效期为687 d.结论]用经典恒温法预测中药材大黄有效期,结论可靠.
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| 关 键 词： | 大黄(RADIX ET RHIZOMA RHEI) 经典恒温试验 含量测定 有效期 |
Research on the Period of Validity of Rhubarb |
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| Institution: | YANG Lei et al(The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine,Changsha,Hunan 410007) |
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| Abstract: | Objective] To study the period of validity of traditional Chinese medicine rhubarb.Method] Easily oxidized rhubarb was selected.Based on classic constant temperature experiment,contents of rhein,archen,physcion and aloe-emodin were detected by HPLC.The change law of the effective components contents in rhubarb was deduced.Result] Changes of rhein,archen,physcion and aloe-emodin contents were followed the first-order reaction law.Under the storage condition of 20 ℃,the change rate constant of rhubarb was K=1.585×10-5;and the period of validity of this batch of rhubarb was 687 d.Conclusion] It was feasible to forecast the validity period of rhubarb by classic constant temperature experiment,and the result was reliable. |
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| Keywords: | Rhubar Classic constant temperature experiment Content determination Validity period |
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