Sesquiterpene lactones from Saussurea involucrata |
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| Authors: | Xiao Wan Li Xian Li Ning Bolati Makabili Wang Xinjun Jia Xiaoguang Zhao Yuqing |
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| Institution: | aShenyang Pharmaceutical University, Shenyang 110016, People's Republic of China;bXinjiang Institute of Chinese Materia Medica and Ethnodrug Urumqi 830002, People's Republic of China;cKey Laboratory of Structure-Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People's Republic of China |
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| Abstract: | Bioassay-directed separation of the ethyl acetate extract from the aerial parts of Saussurea involucrata (Kar. et Kir. ex Maxim) led to the isolation of three new sesquiterpene lactones sausinlactones A (1), B (2), C (3) and six known ones (4–9). The structures were established by spectroscopic data (UV, IR, HRESIMS, 1D and 2D NMR). CD technique was also employed to determine the absolute configurations of new compounds 1–3. The anti-inflammatory activities of compounds 1–9 and antitumor activities of new compounds 1–3 were tested. The results presented that compounds 5 and 6 were responsible for anti-inflammatory activities, and compounds 1 and 2 showed significant cytotoxic activities against A549 cells. |
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| Keywords: | Saussurea involucrate Guaiane-type sesquiterpene lactones CD technique Anti-inflammatory activities Cytotoxic activities |
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