Cytotoxic sesquiterpenoids from the fruits of Lindera communis |
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| Authors: | Deng Zhipeng Zhong Hao Cui Shuxiang Wang Fengling Xie Yanying Yao Qingqiang |
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| Institution: | aInstitute of Materia Medica, Shandong Academy of Medical Sciences, Jinan, 250062, China |
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| Abstract: | A new sesquiterpenoid, namely Linerenone (1), together with three known sesquiterpenoids (2–4), were isolated from the fruits of Lindera communis. Their structures were determined by extensive spectroscopic analysis including 1D, 2D-NMR and HR-MS spectra. Compound 1 showed significant cytotoxic activity against H460, ES2 and DU145 cancer cells with IC50 of 2.1 μg/mL, 2.8 μg/mL and 3.0 μg/mL, respectively. |
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| Keywords: | Lindera communis Sesquiterpenoid Cytotoxicity |
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