| 云南小粒咖啡活性成分研究 |
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| 引用本文： | 疏 义 邱明华. 云南小粒咖啡活性成分研究[J]. 安徽农业科学, 2014, 0(10): 3062-3063,3066 |
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| 作者姓名： | 疏 义 邱明华 |
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| 作者单位： | [1]合肥工业大学生物与食品工程学院,安徽合肥230009 [2]中国咖啡工程研究中心,云南芒市678499 |
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| 基金项目： | 国家基础性研究专项（SB2007FY400）;中国咖啡工程研究中心项目（2013P001）. |
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| 摘 要： | 对云南小粒咖啡中度烘烤的熟咖啡豆进行化学成分研究,并从其提取物中分离得到2个已知的贝壳杉烷型的二萜,通过多种一维和二维谱学方法(HSQD、HMBC、ROESY、COSY),并结合相关参考文献,确定了它们化学结构。其中化合物1为mozambioside(1),化合物2为mascaroside(2)。运用MTT检测法对化合物1和2进行了细胞毒活性筛选,结果显示,这些提取物对HL-60、SMMC-7721、A-549、MCF-7以及SW480细胞有较弱的细胞毒活性。
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| 关 键 词： | 云南小粒咖啡 熟咖啡豆 二萜 结构鉴定 细胞毒活性 |
Studies on the Chemical Constituents and Bioactivity of Coffea arabica |
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| SHU Yi,QIU Ming-hua. Studies on the Chemical Constituents and Bioactivity of Coffea arabica[J]. Journal of Anhui Agricultural Sciences, 2014, 0(10): 3062-3063,3066 |
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| Authors: | SHU Yi QIU Ming-hua |
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| Affiliation: | ( School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei, Anhui 230009 ; Coffee Engineering Research Centre of China, Mangshi, Yunnan 678499) |
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| Abstract: | Two known diterpenoid glucosides, named mozambioside （ 1 ）, mascaroside （2） were isolated from the acetone extracts of the roasted coffee bean of Coffea arabica growing in Yunnan. Their chemical structures were established by extensive spectroscopic analysis inclu- ding 1D and 2D NMR （ HSQC, HMBC, COSY and ROESY） and by comparison with the published data. Biological evaluation showed that the isolates had weak cytotoxieities against HL-60, SMMC-7721, A-549, MCF-7 and SW480 ceils. |
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| Keywords: | Coffea arabica Roasted coffee bean Diterpenes Structural identification Cytotoxicities |
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