Effect of SC58125 on cell proliferation and apoptosis in HepG-2 cells |
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| Authors: | KE Xiao-long LI Hong-liang CHEN Dan-dan REN Xian-da ZHANG Hai-wei CHEN Xiao-dong XIONG Ai-hua |
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| Institution: | 1.Department of General Surgery, First Afficiated Hospital, Guangdong Medical College, Zhanjiang 524001, China;2.Department of Pharmacology, Medical College of Jinan University, Guangzhou 510632, China;3.Department of Cardiology, First Afficiated Hospital, Sun Yet-sen University of Medical Sciences, Guangzhou 510089, China;4.Department of Pathology, Medical College of Jinan University, Guangzhou510632, China |
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| Abstract: | AIM: To clarify the effect of SC58125 on cell proliferation and apoptosis in HepG-2 cells and explore the molecular mechanisms. METHODS: Cell culture, MTT, TUNEL, DNA ladder, flow cytometry and Western blot analysis were employed in the present study. RESULTS: SC58125 inhibited the growth of HepG-2 cells and induced the apoptosis. Furthermore, it arrested G0/G1 phase and inhibited S phase in HepG-2 cells. Depressed expression of P33cdk2, P34cdc2, cyclin B1, cyclin E, Mpm-2, Rb, PCNA proteins were found in HepG-2 cells treated with SC58125. CONCLUSION: SC58125 inhibits cell proliferation and induces apoptosis, which may be related to the altered low protein levels of P33cdk2, P34cdc2, cyclin B1, cyclin E, Mpm-2, Rb, PCNA. |
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| Keywords: | Anti-inflammatory agents non-steroidal Apoptosis Liver neoplasms SC58125 |
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