Protective effects of diltiazem on liver,pancreas and small intestine in hemorrhagic-shock canine

AIM: To investigate the protective effects of diltiazem (Dil) on liver, pancreas and small intestines in hemorrhagic-shock canines and its mechanism. METHODS: The canines were bled to a mean arterial pressure (MAP) of 5.33-6.67 kPa for 30 min to produce the model of shock. During the shock, the dogs received water-soluble calcium channel blocker Dil or normal saline. The MAP was kept at the level for 90 min, then the total blood which was bled previously was reperfused. They were observed for 240 min. RESULTS: Dil could significantly elevated MAP of the hemorrhagic-shock canines (P<0.01) and the activity of superoxide dismmutase (SOD) of pancreas tissue (P<0.01), also it could decrease content of malondialdehyde (MDA) of the liver, pancreas and small intestine tissues (P<0.01). Electron microscope data indicated that Dil-treated dogs have a normal ultrastructure in the liver, pancreas and small intestine tissues. CONCLUSION: Dil can protect the structure and function of the liver, pancreas and small intestine in hemorrhagic-shock canines.