The relationship between the activity of phospholipase A2 and chronic hypoxic pulmonary hypertension |
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| Authors: | LIANG Biao CHEN Li-yan JIN Xun-jie PENG Bo |
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| Institution: | 1. Institute of Respiratory Disease, Guangdong Medical College, Zhanjiang 524021, China;
2. Department of Bone Surgery, Guangdong Medical College, Zhanjiang 524021, China |
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| Abstract: | AIM:To study the relationship between the activity of phospholipase A2 (PLA2) and chronic hypoxic pulmonary hypertension. METHODS:29 healthy SD rats were randomly divided into normal control group, chronic hypoxic group and hypoxia plus Polidatin (PD) group. The model of rat chronic hypoxic pulmonary hypertension was made by method of intermittent isobaric hypoxia for 21 days. The mean pulmonary arterial pressure (mPAP) was measured by inserting a microcatheter into the pulmonary artery. RESULTS:After exposing hypoxia for 21 days, the mPAP, R/L+S, the PLA2 activity, TXB2, MDA in plasma and lung homogenate increased significantly, while 6-k-PGF1α, SOD decreased significantly. Pretreatment with PD could relieve the changes mentioned above.CONCLUSION:PLA2 plays an important inducing role through its metabolic products and the interactional radicals in the formation of chronic hypoxic pulmonary hypertension. |
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| Keywords: | Phospholipases A Inflammation Anoxia Rats Hypertension pulmonary |
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