Role of calcineurin in airway remodeling in guinea pig model of asthma |
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Authors: | CHEN Ya-hong ZHAO Ming-wu FU Min-gui YAO Wan-zhen WANG Xiao-hong WANG Jian-li TANG Chao-shu |
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Institution: | 1. Respiratory Department, the Third Hospital, Beijing University, Beijing 100083, China;
2. Institute of Cardiovascular Research, the First Hospital, Beijing University, Beijing 100034, China |
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Abstract: | AIM:To investigate the role of calcineurin (CaN) in airway remodeling in guinea pig model of asthma.METHODS:Male guinea pigs were randomly divided into three groups: control, asthma group and CsA group. The following parameters were measured: 1. The protein content, cell count and differential count of BALF; 2. The amount of 3H]-TdR incorporation into central airway smooth muscle; 3. The mean thickness of airway wall and airway smooth muscle of small airwaysl; 4.CaN activity of trachea and lung tissue.RESULTS:1. The protein content, cell count and eosinophil of BALF in CsA group were 46%, 51% and 60% lower than those in asthma group, respectively (P<0.01); 2. 3H]-TdR incorporation in CsA group was 22% lower than that in asthma group (P<0.05);3. The mean thickness of airway wall and airway smooth muscle were 34% and 37% less in CsA group than those in asthma group, respectively (P<0.01); 4. CaN activity of lung tissue and trachea were 52% and 44% lower in CsA group than those in asthma group, respectively (P<0.01).CONCLUSION:CsA reduced airway remodeling in guinea pig model of asthma, indicating the role of CaN in the airway remodeling. |
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Keywords: | Asthma Cyclosporine Calmodulin Guinea pigs |
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