Poly(ADP-ribose) polymerase and cell injury |
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| Authors: | ZHU Tie-nian ZHAO Rui-jing LING Yi-ling |
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| Affiliation: | 1.Department of Respiratory Medicine, the Fourth Hospital;2.Department of Immunology, ;3.Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China |
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| Abstract: | ![]()
Poly(ADP-ribose) polymerase (PARP) is a protein-modifying and nucleotide-polymerizing enzyme. As a critical element in DNA repair, PARP can be activated by DNA strand breaks. Excessive activation of PARP, however, can deplete NAD+and ATP, leads to cell death. Cleavage of PARP by activated caspase-3 play an important role in cell apoptosis. |
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| Keywords: | Necrosis Apoptosis Polynucleotide synthetases |
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