The expression of adrenomedullin mRNA in the right ventricle in chronic hypoxic rats |
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| Authors: | LI Yao-jun ZHANG Zhen-xiang XU Yong-jian |
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| Institution: | 1. Department of Respiratory Diseases, Luohe First people's Hospital, Luohe 462000, China;
2. Department of Respiratory Diseases, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | AIM: To study the role of adrenomedullin(AM) in the pathogenesis of hypoxic pulmonary hypertension. METHODS: Rats were exposed to chronic hypoxia for 14 days. After the measurement of the right ventricular systolic pressure (RVSP), the rats were executed. The weight of the right ventricle (RV), the left ventricle(LV) and the ventricular septum(SP) were determined. The ration RV/(LV+SP) was used to express the thickness of RV. In situ hybridization was used for the detection of the expression of AM mRNA in the lung and RV. RESULTS: The RVSP in the hypoxic group was (63.63±3.42) mmHg,which was significantly higher than that in control group (34.13±3.40) mmHg]. The RV/(LV+SP) in hypoxic group was 0.439±0.039,which was increased obviously when compared with that of control (0.230±0.025). The level of AM mRNA expressed in the RV in the hypoxia group was significantly higher than that in the control group. CONCLUSION: The expression of AM mRNA in RV increased in the hypoxic condition, which suggests that AM may attenuate the inappropriate increase in pulmonary artery pressure. |
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| Keywords: | Anoxia Hypertension pulmonary Adrenomedullin RNA messenger |
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