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The genetic susceptibility of HLA-DRB1 alleles in esophageal neoplasm of Hubei Han Chinese |
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| Authors: | LIN Jun SUN Jie ZHOU Yan HUANG Xing XIONG Ping WANG Ya-ping DENG Chang-sheng |
| Institution: | 1. Department of Gastroenterology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China; 2. Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; 3. State Key Lab, Institute of Hydrobiology, The Chinese Academy of Sciences, Wuhan 430077, China |
| Abstract: | AIM: To probe into the genetic susceptibility of HLA-DRB1 alleles to esophageal neoplasm in Hubei Han Chinese. METHODS: HLA-DRB1 gene polymorphism in 42 patients with esophageal neoplasm and 136 normal control subjects was studied by PCR and sequence. RESULTS: Allele frequency of HLA-DRB1 *0901 allele was significantly higher in esophageal cancer patients than those in normal controls(0.2500 vs 0.1397, P =0.028; the odds ratiO2.053; etiologic fraction 0.1282).There were no association between the rested HLA-DRB1 alleles with patients. CONCLUSION: Individuals carrying HLA-DRB1 *0901 may be susceptible to esophagealo carcinoma, its nucleotide sepuence approachs to the corresponded allele sequence(exoN2)published in GenBank. |
| Keywords: | Esophageal neoplasms HAL-DR antigens Polymerase chain reaction Genetics |
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