Expression of IL-6 mRNA in endometrium with endometriosis |
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| Authors: | ZHENG Hui LI Hong-yi WANG Zi-neng ZHAO Ying-she YU Li HE Si-cun BAI Zhi-quan ZHOU Zuo-yan YAO Ping WANG Yue-chun |
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| Institution: | 1. Department of Physiology, Medical College of Jinan University, Guangzhou 510632, China;
2. Department of Obstetrics and Gynecology, Medical College of Jinan University, Guangzhou 510632, China;
3. Department of Biochemistry, Medical College of Jinan University, Guangzhou 510632, China;
4. Sun Yat-sen University of Medical Sciences, Guangzhou 510089, China |
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| Abstract: | AIM: The purpose of the present study was to explore the relationship between interleukin-6 mRNA expression and endometriosis. METHODS: Using the rat model, IL-6 mRNA expression in the endometrium was examined by RT-PCR. RESULTS: The expression of IL-6 mRNA in control rats did not change at 2, 4, 6 and 8 weeks after sham operation (P>0.05), but in model rats it gradually increased at 2, 4, 6 and 8 weeks after endometriosis (P<0.01). The expression of IL-6 mRNA in uterine endometrium with endometriosis was lower than in endometriotic tissue, but higher than in endometrium from healthy controls. CONCLUSION: The IL-6 mRNA expression may contribute to the development of endometriosis . The increase in IL-6 mRNA expression may promote the implantation and growth of endometriotic tissue. |
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| Keywords: | Interleukin-6 RNA messenger Endometriosis Rats |
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