Characteristics of energy metabolism in brain mitochondria of rats exposed to hypoxia |
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| Authors: | GAO Wen-xiang LIU Jun-ze WU Li-ping CAI Ming-chun |
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| Institution: | 1. Department of Pathophysiology & Institute of High Altitude, the Third Military Medical University, Chongqing 400038, China; 2. Xijing Hospital, the 4th Military Medical University, Xian 710032, China |
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| Abstract: | AIM:To explore the characteristics of energy metabolism in brain mitochondria of rats exposed to acute and chronic hypoxia. METHODS: Animal grouping: Wistar rats were randomized into acute hypoxic group (AH), chronic hypoxic group (CH) and the control. Respiratory function, F0F1-ATPase activity, mitochondrial ATP, ADP and AMP contents and ATP production rate were measured respectively. RESULTS: In AH, brain mitochondrial respiratory state IV (ST4) was increased, while respiratory control rate (RCR), mitochondrial ATP content, ATP production rate and F0F1-ATPase activity were decreased respectively. In CH, ST4, RCR, mitochondrial ATP content and F0F1-ATPase activity were reversed partially.CONCLUSION: Acute hypoxia may impair brain mitochondria energy metabolism by way of depressing mitochondrial oxidative phosphorylation and ATP production and these parameters gain partial reablement during chronic hypoxia. |
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| Keywords: | Anoxia Mitochondria Oxidative phosphorylation Energy metabolism Brain |
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