Relationship between thromboxane synthase gene and prostacyclin synthase gene expression and pulmonary hypertension induced by hypoxic hypercapnia |
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| Authors: | ZENG Hai-huan WANG Liang-xing CHEN Shao-xian WANG Ming-shan FAN Xiao-fang |
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| Institution: | 1. Institute of Cor Pulmonale, Department of Respirology;
2. Department of Pathology, First Hospital, Wenzhou Medical College, Wenzhou 325003, China |
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| Abstract: | AIM: To study the effect of chronic hypoxic hypercapnia on gene expression of thromboxane synthase and prostacyclin synthase in pulmonary arterioles. METHODS: Sprague-Dawley rats were randomly divided into two groups: control group and hypoxic hypercapnic group. TXS mRNA and PGI2-SmRNA were observed in pulmonary arterioles by in situ hybridization. RESULTS: mPAP, weight ratio of right ventricle (RV) to left ventricle plus septum(LV+S), contents of TXB2 and 6-keto-PGF1α in plasma and lung and TXS mRNAin pulmonary arterioles were much higher in rats of hypoxic hypercapnic group than those of control group. Differences of PGI2-SmRNA in pulmonary arterioles were not significant in two groups. Light microscopy showed hypertrophy of vessel smooth muscle cells and vessel cavity straitness were found in hypoxic hypercapnic group. CONCLUSION: Changes of gene expressions of thromboxane synthase and prostacyclin synthase and imbalance of TXA2/PGI2 may play an important role in hypoxic hypercapnic pulmonary hypertension. |
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| Keywords: | Thromboxane synthase Prostacyclin synthase Anoxia Hypercapnia Hypertension pulmonary Genes |
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