| Abstract: | Determination of nitrous oxide (N2O) potency was accomplished by extrapolation using the concepts of minimum alveolar concentration (MAC) and additivity among inhalation anesthetics. Halothane and isoflurane anesthetic requirement (alveolar concentration) necessary to achieve MAC in 9 pigs decreased with each successive increase in the percentage of inspired N2O (25%, 50%, 75%). Halothane and isoflurane MAC was determined to be 0.94 +/- 0.03 and 1.75 +/- 0.01 volumes percent, respectively. Halothane and isoflurane requirements decreased to 0.74 +/- 0.02, 0.66 +/- 0.02, and 0.58 +/- 0.02; and to 1.56 +/- 0.02, 1.38 +/- 0.02, and 1.08 +/- 0.03 volumes percent with 25%, 50%, and 75% N2O, respectively. The line of best fit derived from regression analysis of the combined data (isoflurane and halothane MAC values) had a correlation coefficient of 0.987 and an X intercept equivalent to 195% N2O. The potency of N2O in pigs was similar to that of other domesticated mammals and reduced halothane and isoflurane anesthetic requirements by approximately 50% of the reduction observed in human beings. |
