Median effective dosage of propofol for induction of anesthesia in dogs. |
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| Authors: | G C Watney L S Pablo |
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| Affiliation: | Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0136. |
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| Abstract: | The median effective dosage (ED50) of propofol for induction of anesthesia was determined in 25 dogs premedicated with acepromazine, 0.05 mg/kg of body weight, and in 35 unpremedicated dogs. The ED50 was found to be 2.2 mg/kg in premedicated dogs and was 3.8 mg/kg in unpremedicated dogs. The mean +/- SD total dosage of propofol required to induce anesthesia in premedicated animals was 2.8 +/- 0.5 mg/kg and was 4.7 +/- 1.3 mg/kg in unpremedicated animals. Signs of excitement were observed in 5 of the unpremedicated dogs, but in none of those that were premedicated. |
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