山羊毛霉菌病临床与病理学观察

以１０７个／ｍｌ微小根毛霉（Ｒｈｉｚｏｍｕｃｏｒｐｕｓｉｌｕｓ）孢囊孢子悬液颈静脉接种２月龄山羊，每只５ｍｌ，每日１次，连续３日，经８８ｄ观察３／４只山羊死亡。病羊临床表现精神沉郁，消瘦，体温升高，腹泻，后肢瘫痪，白细胞总数及嗜中性白细胞成倍增加，全血ＧＳＨ－ＰＸ活性降低，Ｓ－ＧＯＴ、Ｓ－ＧＰＴ和ＡＫＰ活性升高，血清胆固醇值上升，但以上各项血液生化指标变化与对照羊相比差异不显著（ｐ＞０．０５）。病理变化为全身扩散性毛霉菌病，其典型病变在肺脏，整个肺脏遍布灰白色圆形小结节。镜险肺结节中心为毛霉菌丝或碎片，周围淋巴细胞、单核细胞包绕。腿肌大部分肌束呈凝固性坏死，周围微血管内形成血栓

OBSERVATIONS OF THE CLINICAL AND PATHOLOGICAL MANIFESTATIONS OF MUCORMYCOSIS IN GOATS

2 month old goats were inoculated intraveously with 5ml suspended liquid containing 10 7 Rhizomucor pusillus sporangiospore per mililitre once a day for three days.During 88 days of observations,34 goats died.The clinical signs of the sick goats were depression,emaciation,fever,diarrhea,paralysis of legs.The total WBC and neutrophils had doubled and redoubled.The activities of SGOT,SGPT and AKP increased.But the activity of whole blood GSH PX was decreased.The value of cholesterol raised.The biochemical indexes between the inoculated and control groups were not significant(p>0 05).Post mortem:diffuse mucormycosis in whole body.The typical lesions in the lungs were scattered with a large quantities of whitegray nodes.Mi croscopic changes were mucoraceous hyphae or fragmeuts in the node center,with lymphocytes,monocytes around it.A large number of muscles in legs were necrotic and thrombosis in blood vessels.