The pharmacokinetics of promethazine after intravenous administration in camels |
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| Authors: | Wasfi I A Barezaiq I M Alkatheeri N Hadi A A Boni N S Almuhrami A M Elghazali M |
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| Institution: | Camelracing Laboratory, Forensic Science Laboratory, P O Box 253, Abu Dhabi, United Arab Emirates. iawasfi@emirates.net.ae |
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| Abstract: | The pharmacokinetics of promethazine were determined in seven camels (Camelus dromedarius) after an intravenous dose of 0.5 mg kg body weight.-1 The data obtained (median and range) were as follows: the elimination half-life (t1/2 beta) was 5.62 (2.84-6.51) h; the steady state volume of distribution (Vdss) was 8.90 (7.10-12.00) L kg-1, total body clearance (CT) was 24.5 (17.22-33.65) ml kg-1 min-1 and renal clearance (Clr) was 4.81 (1.97-5.48) ml kg-1 min-1. |
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