Survival of rough and smooth strains of Brucella abortus in bovine mammary gland macrophages |
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| Authors: | B G Harmon L G Adams M Frey |
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| Institution: | Department of Veterinary Pathology, College of Veterinary Medicine, Texas A&M University, College Station 77843-4463. |
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| Abstract: | Chronic bovine brucellosis is characterized by persistent infection of the mammary gland. The interaction of live Brucella abortus with bovine mammary gland macrophages was studied in vitro. Opsonization of smooth B abortus strain 2308 and rough strain 45/20 was required for phagocytosis by mammary gland macrophages. When opsonized with specific antiserum, strains 2308 and 45/20 stimulated a considerable oxidative burst when phagocytized by mammary gland macrophages. Intracellular survival rates for strain 2308 were significantly higher than those for strain 45/20. After being phagocytized, B abortus localized in phagosomes and phagolysosomes of mammary gland macrophages. |
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