| 苦皮藤素类似物的合成与结构鉴定 |
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| 引用本文： | 张继文,吴文君,田暄.苦皮藤素类似物的合成与结构鉴定[J].农药学学报,2004,6(3):15-25. |
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| 作者姓名： | 张继文 吴文君 田暄 |
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| 作者单位： | 1.西北农林科技大学 农药研究所 |
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| 基金项目： | 国家自然科学基金重点项目(30130130). |
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| 摘 要： | 以苦皮藤Celastrus angulatus Max.提取物水解产物中的多羟基β-二氢沉香呋喃为原料,合成了对粘虫Mythimna separata具有毒杀活性的苦皮藤素(Celangulin)类似物,并在活性追踪的指导下分离得到了两个具有杀虫活性的苦皮藤素类似物 A和B, 其结构经核磁共振谱、快原子轰击质谱、高分辨质谱等波谱学方法鉴定为2β,6α,8β,13-四异丁酰氧基-1β,4α,9α-三羟基-β-二氢沉香呋喃及1β,2β,6α,8β,13-五异丁酰氧基-4α,9α-二羟基-β-二氢沉香呋喃。化合物 A和B 均为新化合物,在20 mg/mL的浓度下对三龄粘虫Mythimna separata的胃毒活性(死亡率)分别为89.5%和93.2%。
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| 关 键 词： | β-二氢沉香呋喃 结构修饰 杀虫活性 |
| 文章编号： | 1008-7303(2004)03-0021-05 |
| 收稿时间： | 3/5/2004 12:00:00 AM |
| 修稿时间： | 2004年3月5日 |
Synthesis and Structure Elucidation of the Celangulin Analogues |
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| ZHANG Ji-wen,WU Wen-jun and TIAN Xuan.Synthesis and Structure Elucidation of the Celangulin Analogues[J].Chinese Journal of Pesticide Science,2004,6(3):15-25. |
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| Authors: | ZHANG Ji-wen WU Wen-jun and TIAN Xuan |
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| Institution: | 1.Institute of Pesticide Science, Northwest Sci-Tech University of Agriculture and Forest, Yangling 712100, China2.National Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China |
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| Abstract: | In order to look for new active compounds,celangulin analogues were synthesized based on the basic hydrolysis of the extract of the root bark of Celastrus angulatus Max. and isolated by bioassay-guided fractionation. Two new active compounds were synthesized and isolated. Their structures were comfirmed as 2β,6α,8β,13-tetraisobutanoyloxy-1β,4α,9α-trihydroxy-β-dihydroagarofuran (A) , 1β,2β,6α,8β,13-pentaisobutanoyloxy-4α,9α-dihydroxy-β-dihydroagarofuran (B) based mainly on NMR and MS spectral data. A and B are new compounds with insecticidal activity against Mythimna soparata. |
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| Keywords: | dihydroagarofuran structure modification insecticidal activity |
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