| 芝芪菌质水提物抗抑郁作用研究 |
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| 引用本文： | 陆明鸣,陆潭,张雪明,张李阳,陈玉胜.芝芪菌质水提物抗抑郁作用研究[J].安徽农业科学,2011,39(18):10818-10819. |
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| 作者姓名： | 陆明鸣 陆潭 张雪明 张李阳 陈玉胜 |
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| 作者单位： | 南京晓庄学院行知学院,江苏,南京,211171;南京晓庄学院生物化工与环境工程学院,江苏,南京,210017 |
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| 基金项目： | 江苏省高等学校大学生实践创新项目(2160081) |
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| 摘 要： | 目的]探讨通过“固体双向发酵”工程技术生产的药性茵质的抗忧郁功效。方法]将雄性ICR小鼠随机分为5组，即阴性对照组（0．9％生理盐水）、阳性对照组（市售盐酸氟西汀）、高剂量组（690：0rtig／kg）、中荆量组（345．0mg／kg）和低剂量组（172．5mg／kg），在灌胃给予受试物15d后对各组小鼠进行开场试验（OFT）、悬尾试验（脚）和强迫游泳试验（耐），探讨芝芪茵质对小鼠行为学酌影响。结果]中剂量组芝芪茵质和阳性对照组能显著缩1、ST和FST小鼠悬尾和游泳不动时间；对小鼠开场行为无显著影响。结论]芝芪菌质水提物具有一定的抗抑郁作用。
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| 关 键 词： | 芝芪菌质 抗抑郁 开场试验(OFT) 悬尾试验(ST) 强迫游泳试验(FST) |
Study on Anti-depressant Effect of Water Extract from Zhiqi Medicinal Fungal Substance |
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| LU Ming-ming et al.Study on Anti-depressant Effect of Water Extract from Zhiqi Medicinal Fungal Substance[J].Journal of Anhui Agricultural Sciences,2011,39(18):10818-10819. |
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| Authors: | LU Ming-ming |
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| Institution: | LU Ming-ming et al(School of Xingzhi,Nanjing Xiaozhuang University,Nanjing,Jiangsu 211171) |
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| Abstract: | Objective] To explore the antidepressant effects of medicinal fungal substance which was produced from the engineering technology of bidirectional solid fermentation.Method] Male ICR mice were randomly subdivided into five groups namely negative control group(0.9% normal saline),positive control group(fluoxetine hydrochloride purchased from market),high dosage group(690.0 mg/kg),middle dosage group(345.0 mg/kg)and low dosage group(172.5 mg/kg).The mice were given corresponding solution per day respectivel... |
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| Keywords: | Zhiqi medicinal fungal substance Antidepressant Open-field test(OFT) Tails suspension test(TST) Forced swimming test(FST) |
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