茶叶中EGCG对高脂大鼠的降脂作用研究

目的]研究表没食子儿茶素没食子酸酯（EGCG）对高脂大鼠血脂调节作用。方法]采用高脂大鼠模型，设正常对照组（I组，喂基础饲料）、模型对照组（Ⅱ组，喂高脂饲料）、试验组（Ⅲ、Ⅳ组，喂高脂饲料，并每日分别灌喂0．5、1．0g／kg的EGCG），连续喂饲30d，测定其血清中TC、TG、HDL．C和LDL—C含量。结果]Ⅲ、Ⅳ试验组TC、LDL—C含量极显著低于Ⅱ组（P〈0．01）Ⅲ、Ⅳ组TG含量显著低于Ⅱ组（P〈O．05）；Ⅲ、Ⅳ组HDL．C含量较Ⅱ组变化不明显；IV组HDL—C含量略有升高，但差异不显著；Ⅲ、Ⅳ组AI值极显著低于Ⅱ组（P〈0．01）。结论]EGCG具有降血脂作用。

Study on Effects of Epigallocatechin Gallate in Tea on Decreasing Blood Lipid of High-lipid Rats

Objective] To study the decreasing blood lipid effect of epigallocatechin gallate(EGCG) in high-lipid rats.Method] Using high-lipid rats model,four groups were subdivided including normal CK(Ⅰ,feeding normal diet),model CK(Ⅱ,feeding high-fat diet) and test group(Ⅲ,Ⅳ,feeding high fat diet and giving EGCG of 0.5 and 1.0 g/kg,respectively).The rats in the four groups all were given for 30 d and were determined content of TC,TG,HDL-C and LDL-C in serum.Result] Contents of TC and LDL-C in rats tested in group Ⅲ and Ⅳ were highly significantly lower than those in group Ⅱ(P<0.01);TG in group Ⅲ and Ⅳ was significantly lower than that in group Ⅱ(P<0.05).HDL-C in group Ⅲ and Ⅳ did not vary significantly in comparison with group Ⅱ and rats in group Ⅳ were a little higher in HDL-C.Compared with group Ⅱ,rats in group Ⅲ and Ⅳ were highly lower in AI value(P<0.01).Conclusion] EGCG is provided with effect of reducing blood lipid.