Secosteroids and Norcembranoids from the Soft Coral Sinularia nanolobata |
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| Authors: | Yen-Ju Tseng Shang-Kwei Wang Chang-Yih Duh |
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| Institution: | 1.Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mail: ;2.Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan;3.Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan |
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| Abstract: | Two new 9,11-secosteroids, 22α-acetoxy-24-methylene-3β,6α,11-trihydroxy-9,11-seco-cholest-7-en-9-one (1) and 11-acetoxy-24-methylene-1β,3β,6α-trihydroxy-9,11-seco-cholest-7-en-9-one (2), as well as two known norcembranoids, 5-epi-sinuleptolide (3) and sinuleptolide (4), were isolated from the soft coral Sinularia nanolobata. The structures of these metabolites were elucidated on the basis of extensive spectroscopic analysis. The anti-HCMV (human cytomegalovirus) activity of 1–4 and its cytotoxicity against selected cell lines were evaluated. |
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| Keywords: | soft coral Sinularia nanolobata secosteroid cytotoxicity |
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