Flavonoid glycosides from Microtea debilis and their cytotoxic and anti-inflammatory effects |
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| Authors: | Naisheng BaiKan He Marc RollerChing-Shu Lai Xi ShaoMin-Hsiung Pan Antoine BilyChi-Tang Ho |
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| Institution: | a Naturex, Inc., 375 Huyler St., South Hackensack, NJ 07606, United Statesb Naturex SA, Site d''Agroparc BP 1218, 84911 Avignon Cedex 9, Francec Department of Seafood Science, National Kaohsiung Marine University, No.142, Haijhuan Rd., Kaohsiung 81143, Taiwand Department of Food Science, Rutgers University, 65 Dudley Road, New Brunswick, NJ 08901, United States |
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| Abstract: | Two new 5-O-glucosylflavones, 5-O-β-d-glucopyranosyl cirsimaritin (1) and 5, 4′-O-β-d-diglucopyranosyl cirsimaritin (2), four known flavonoids, cirsimarin (3), cirsimaritin (4), salvigenin (5), 4′, 5-dihydroxy-7-methoxyflavone (6), and a norisoprenoid, vomifoliol (7), have been isolated from the aerial parts of Microtea debilis. All isolates were tested for cytotoxicity in human cancer cell lines (Hep G2, COLO 205, and HL-60) and anti-inflammatory activities in LPS-treated RAW264.7 macrophages. Compound 6 was found to be a potent inhibitor to nitrite production in macrophages. Compounds 2, 4, 6, and 7 showed moderate anti-proliferative activity against COLO-205 cells with IC50 values of 7.1, 13.1, 6.1, and 6.8 μM, respectively. |
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| Keywords: | Microtea debilis d-Glucopyranosyl cirsimaritin" target="_blank">5-O-β-d-Glucopyranosyl cirsimaritin 5 4&prime d-Diglucopyranosyl cirsimaritin" target="_blank">-O-β-d-Diglucopyranosyl cirsimaritin Human cancer cell lines (Hep G2 COLO 205 HL-60) Anti-inflammatory |
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