| 灵雷菌质提取物体内抗肿瘤作用的实验研究 |
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| 引用本文： | 熊浩仲,谢小梅,苏明声,庄毅,周雪娥,张普照,舒任庚.灵雷菌质提取物体内抗肿瘤作用的实验研究[J].中国食用菌,2009,28(1). |
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| 作者姓名： | 熊浩仲 谢小梅 苏明声 庄毅 周雪娥 张普照 舒任庚 |
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| 作者单位： | 1. 江西中医学院菌物药研究中心,江西,南昌,330004
2. 江西中医学院现代中药制剂教育部重点实验室,江西,南昌,330004 |
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| 基金项目： | 科技部国际合作项目，江西省卫生厅中医药科研计划 |
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| 摘 要： | 采用小鼠肉瘤(S180)移植性肿瘤模型,观察灵雷菌质乙酸乙酯部位、正丁醇部位、石油醚部位和水部位提取物的肿瘤抑制作用,并测定小鼠的胸腺指数及脾脏指数。结果表明所有的提取物都呈现出明显的抑瘤效果,抑瘤率均大于35%,其中部分正丁醇部位的抑瘤率达到了68.88%。抑瘤效果由弱至强的顺序为石油醚部位<水部位<乙酸乙酯部位<正丁醇部位,而胸腺指数与脾脏指数则显示只有乙酸乙酯部位组有较明显的免疫抑制效果。双向性固体发酵可降低雷公藤的毒性,尤其正丁醇部位和水部位的毒性可能较弱。
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| 关 键 词： | 双向性固体发酵 雷公藤 灵雷菌质 提取物 抗肿瘤作用 |
Experimental Research on Anti-tumor Effect of Fermentation Substance on Tripterygium in Vivo |
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| XIONG Hao-zhong,XIE Xiao-mei,SU Ming-sheng,ZHUANG Yi,ZHOU Xue-e,ZHANG Pu-zhao,SHU Ren-geng.Experimental Research on Anti-tumor Effect of Fermentation Substance on Tripterygium in Vivo[J].Edible Fungi of China,2009,28(1). |
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| Authors: | XIONG Hao-zhong XIE Xiao-mei SU Ming-sheng ZHUANG Yi ZHOU Xue-e ZHANG Pu-zhao SHU Ren-geng |
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| Institution: | 1 (1.Mycomedicine Research Center; Jiangxi University of Traditional Chinese Medicine; Nanchang Jiangxi 330004; 2.Key Laboratory of Modern Preparation of TCM Jiangxi University of Traditional Chinese Medicine; Nanchang Jiangxi 330004); |
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| Abstract: | The transplanting tumor model of mice sarcoma S180 was used to observe the anti-tumor effect of fermentation substance on Tripterygium, such as ethyl acetate part, n-butyl alcohol part, petroleun ether part and water part, and the thymus index and spleen index of mice had been measured. The results showed that all extracts had a significant inhibitory effect on tumor. The tumor inhibitory rates were all above 35% and the n-butyl alcohol part reached 68.88%. The inhibitory effect on tu- mor from low to high ... |
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| Keywords: | Bi-directional solid fermentation Triperygium wilfordii Hook Fermentation substance on Tripterygium Extract Anti-tumor effect |
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