| 蠕虫及其产物对宿主免疫调节作用的研究进展 |
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| 引用本文： | 孙树民,高志刚,杜立银,东彦新.蠕虫及其产物对宿主免疫调节作用的研究进展[J].中国农学通报,2015,31(32):16-21. |
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| 作者姓名： | 孙树民 高志刚 杜立银 东彦新 |
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| 作者单位： | 内蒙古民族大学动物科学技术学院,内蒙古民族大学动物科学技术学院,内蒙古民族大学动物科学技术学院,内蒙古民族大学动物科学技术学院 |
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| 基金项目： | 国家自然科学基金项目“猪带绦虫/囊尾蚴不同发育时期标识性抗原基因的筛选”(31460658)，“我国旋毛虫属分类鉴定和分子进化研究”(31160504)；中国博士后科学基金项目“旋毛虫引发宿主高度免疫抑制的分子机制研究”(2012M520674)；内蒙古民族大学市校合作项目“提高肉用母牛繁殖性能的中药筛选与应用研究”(SXYB2012088)。 |
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| 摘 要： | 文章阐述了蠕虫及产物对宿主机体免疫调节的分子作用机制及在疾病治疗方面的潜在能力。蠕虫及产物主要是通过刺激免疫相关细胞增减与细胞因子表达升降来调节宿主的免疫。免疫调节过程与虫体入侵后持续不断产生的衍生物密切相关,蠕虫感染后其分泌物选择性作用于免疫细胞,刺激宿主免疫系统应答,增强或抑制免疫相关因子来实现对宿主机体的免疫调节作用。慢性蠕虫感染对炎症性肠病、过敏性疾病和糖尿病等具有免疫调节作用,此类虫体的感染与这些疾病呈现某种程度的负相关。因此,获知蠕虫及产物对宿主机体免疫调节作用,阐述其免疫调节机制,可以为免疫性疾病治疗药物研发奠定基础。
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| 关 键 词： | 蠕虫 蠕虫产物 免疫调节 |
| 收稿时间： | 2015/5/12 0:00:00 |
| 修稿时间： | 2015/8/14 0:00:00 |
Review on Host Immune Regulation by Helminth and Its Products |
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| Sun Shumin,Gao Zhigang,Du Liyin and Dong Yanxin.Review on Host Immune Regulation by Helminth and Its Products[J].Chinese Agricultural Science Bulletin,2015,31(32):16-21. |
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| Authors: | Sun Shumin Gao Zhigang Du Liyin and Dong Yanxin |
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| Institution: | College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao Inner Mongolia 028000),College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao Inner Mongolia 028000),College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao Inner Mongolia 028000),College of Animal Science and Technology, Inner Mongolia University for Nationalities, Tongliao Inner Mongolia 028000) |
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| Abstract: | The article expounded the molecular mechanism of helminth, its products regulating the host immune system and the potential ability in disease treatment. Host immune regulation is conducted by the increase or decrease of immune cells and up or down expression of cytokines stimulated by helminth and its products. The immune regulation process is closely related to the secreta generated after the invasion of helminth. Secreta of helminth act on immune cells selectively after infecting the host, stimulate the host immune system response and enhance or suppress the immune related factors to implement the immune regulation. The chronic infection of helminth can regulate inflammatory bowel disease, allergic disease and diabetes, and this type of infection shows negative correlation with these diseases to some extent. In summary, understanding the regulation of helminth and its products and elucidating immune regulation mechanism will lay foundation for drug research and development of autoimmune disease treatment. |
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| Keywords: | helminth helminth products immune regulations |
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