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| 紫杉醇及紫杉烷的细胞工程生产 | |
| 引用本文： | 高明波,李兴泰,阮成江,范圣第.紫杉醇及紫杉烷的细胞工程生产[J].中国农学通报,2010,26(13):53-57. |
| 作者姓名： | 高明波 李兴泰 阮成江 范圣第 |
| 作者单位： | 1. 生物化学工程国家民委一教育部重点实验室,辽宁,大连,116023;大连民族学院生命科学学院,辽宁,大连,116600 2. 大连民族学院生命科学学院,辽宁,大连,116600 3. 生物化学工程国家民委一教育部重点实验室,辽宁,大连,116023 |
| 基金项目： | 植物细胞培养次生代谢产物生产不稳定的两种新机制 |
| 摘 要： | 紫杉醇是重要的抗癌药物，紫杉烷是紫杉醇的代谢前体或支路代谢产物，具有特殊生理活性。紫杉醇及紫杉烷的药源问题是制约其应用的主要因素。细胞工程技术环境友好，可调控，符合可持续发展战略，生产紫杉醇及紫杉烷富有潜力。本文综述了紫杉醇及紫杉烷的细胞工程生产情况，指出了存在的问题，提出了一些建议。 |
| 关 键 词： | 测土配方施肥 测土配方施肥 水稻 效果 |
| 收稿时间： | 2009-12-18 |
| 修稿时间： | 2010-01-10 |
Production of Taxol and Taxanes by Cell Engineering |
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| Gao Mingbo,Li Xingtai,Ruan Chengjiang,Fan Shengdi.Production of Taxol and Taxanes by Cell Engineering[J].Chinese Agricultural Science Bulletin,2010,26(13):53-57. | |
| Authors: | Gao Mingbo Li Xingtai Ruan Chengjiang Fan Shengdi |
| Institution: | Gao Mingbo1,2, Li Xingtai2, Ruan Chengjiang1,2, Fan Shengdi1 (1Key Laboratory of Biochemical Engineering (SEAC-ME), Dalian Liaoning 116023; 2College of Life Science, Dalian Nationalities University, Dalian Liaoning 116600 |
| Abstract: | Taxol is an important anticancer drug and taxanes are metabolic precursors or branch metabolites of taxol with special physiological activity. Pharmaceutical source is the main problem that restrict their application. Cell engineering is a potential technique to produce taxol and taxanes , being environment friendly, easy to control, in accordance with the strategy of sustainable development. Production of Taxol and taxanes in cell culture is reviewed and some advice is given to solve problems in the research. |
| Keywords: | taxolzz taxaneszz cell engineeringzz research advanceszz |
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