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Antioxidative and Anticancer Activity of Extracts of Cherry (Prunus serrulata var. spontanea) Blossoms
Authors:Bo-Bae Lee  Mi-Ran Cha  Soo-Yeon Kim  Eunju Park  Hae-Ryong Park  Seung-Cheol Lee
Affiliation:(1) Department of Food Science and Biotechnology, Kyungnam University, Masan, 631-701, Republic of Korea;(2) Department of Food and Nutrition, Kyungnam University, Masan, 631-701, Republic of Korea
Abstract:
Organic solvent (methanol, ethanol, and acetone) extracts and water extracts of cherry (Prunus serrulata var. spontanea) blossoms were prepared, and antioxidant activities of the extracts were evaluated. Methanolic CBE (100 μg/ml) showed the highest total phenol content (104.30 μM), radical scavenging activity (34.2%), and reducing power (0.391). The effect of CBE on DNA damage induced by H2O2 in human leukocytes was evaluated by Comet assay. All CBE was a potent dose dependent inhibitor of DNA damage induced by 200 μM of H2O2, methanolic CBE showed the most strong inhibition activity. The methanolic CBE of 500 μg/ml showed 38.8% inhibition against growth of human colon cancer cell line HT-29. These results indicated that cherry blossoms could provide valuable bioactive materials.
Keywords:Prunus serrulata var. spontanea   Extract  Antioxidant  Anticancer
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