Novel mode of action of spinosad: Receptor binding studies demonstrating lack of interaction with known insecticidal target sites |
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Authors: | Nailah Orr |
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Institution: | Dow AgroSciences LLC, Crop-Protection Discovery Group, Bldg. 306/E2/984, 9330 Zionsville Rd., Indianapolis, IN 46268, USA |
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Abstract: | The ability of spinosyn A to either enhance or displace binding to selected insecticidally-relevant receptors was investigated using a number of radioligands including, 3H]imidacloprid and 3H]ivermectin in tissues from the ventral nerve cord (VNC) membranes of the American cockroach, Periplaneta americana and head membranes from the housefly, Musca domestica. In these insect neural tissues, spinosyn A does not appear to alter the binding of a number of radioligands suggesting that spinosyn A does not interact directly with a variety of known receptors, including nicotinic or γ-aminobutyric acid (GABA)-based insecticidal target sites. However, available data are consistent with spinosyn A interacting with a site distinct from currently known insecticidal target sites, thus supporting a novel insecticidal mechanism of action for the spinosyns. |
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Keywords: | Spinosad Spinosyn A Receptor binding Insecticide Periplaneta americana Musca domestica |
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