A B cell-based sensor for rapid identification of pathogens |
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Authors: | Rider Todd H Petrovick Martha S Nargi Frances E Harper James D Schwoebel Eric D Mathews Richard H Blanchard David J Bortolin Laura T Young Albert M Chen Jianzhu Hollis Mark A |
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Institution: | Massachusetts Institute of Technology Lincoln Laboratory, Lexington, MA 02420, USA. thor@ll.mit.edu |
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Abstract: | We report the use of genetically engineered cells in a pathogen identification sensor. This sensor uses B lymphocytes that have been engineered to emit light within seconds of exposure to specific bacteria and viruses. We demonstrated rapid screening of relevant samples and identification of a variety of pathogens at very low levels. Because of its speed, sensitivity, and specificity, this pathogen identification technology could prove useful for medical diagnostics, biowarfare defense, food- and water-quality monitoring, and other applications. |
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