Preliminary studies on the immunomodulatory activity of Cedrus deodara wood oil |
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| Affiliation: | 1. Key Lab of Chemical Biology (MOE), School of Pharmaceutical Sciences, Shandong University, No. 44 Wenhua Xi Road, Jinan, 250012, People''s Republic of China;2. The First Clinical Medical College of Lanzhou University, Lanzhou, 730000, People''s Republic of China;1. Environmental Biomonitoring Laboratory LBE (LR01/ES14), Faculty of Sciences of Bizerta, University of Carthage, Tunisia;2. Laboratory of Transmission, Control and Immunobiology of Infection (11 LR IPT 02), Pasteur Institute, Tunisia;3. Laboratory of Bioactive Substances, Biotechnology Centre in Borj-Cedria Technopol, BP.901, Hammam-lif, 2050, Tunisia;4. Laboratory of Molecular Interactions and Chemical Reactivity and Photochemical UMR CNRS 5623, University of Toulouse, University of Paul Sabatier, 118 Route de Narbonne, F-31062 Toulouse, France;1. Department of Medicinal Chemistry, College of Pharmacy, University of Florida, Gainesville, FL 32610-0485, USA;2. Biomedical Mass Spectrometry Laboratory, Clinical Research Center, University of Florida, Gainesville, FL 32610-0322, USA |
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| Abstract: | ![]()
The volatile oil of Cedrus deodara wood, administered orally at doses of 50 and 100 mg/kg, significantly inhibited neutrophil adhesion to nylon fibers, indicating inhibition of process of margination in the blood vessels. It also significantly inhibited Type III hypersensitivity reaction, i.e. Arthus reaction induced by methylated bovine serum albumin, and Type IV, i.e. delayed type hypersensitivity reaction induced by sheep erythrocytes and oxazolone, indicating an inhibitory effect on humoral and cell-mediated immune responses. |
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