| 几种佐剂对肌肉注射猪支原体肺炎活疫苗免疫刺激能力的增强作用研究 |
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| 引用本文： | 熊祺琰,范志鹏,甘源,孔猛,冯志新,刘茂军,邵国青.几种佐剂对肌肉注射猪支原体肺炎活疫苗免疫刺激能力的增强作用研究[J].中国畜牧兽医,2011,38(10):163-168. |
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| 作者姓名： | 熊祺琰 范志鹏 甘源 孔猛 冯志新 刘茂军 邵国青 |
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| 作者单位： | 1. 江苏省农业科学院兽医研究所农业部动物疫病诊断与免疫重点开放实验室国家兽用生物制品工程技术研究中心,江苏南京,210014
2. 江苏省农业科学院兽医研究所农业部动物疫病诊断与免疫重点开放实验室国家兽用生物制品工程技术研究中心,江苏南京210014;山西农业大学研究生学院,山西太谷030801 |
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| 基金项目： | 江苏省博士后科研资助计划项目(0902063C); 中国博士后科学基金面上资助项目(20090461075); 江苏省农业科技创新基金(cx(10)215); 农业科技成果转化资金项目(2009FB2C100129); 江苏省“333工程”培养资金; “六大人才高峰”资助项目 |
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| 摘 要： | 为增强现有猪支原体肺炎活疫苗的免疫刺激能力以实现肌肉注射免疫,向现有活疫苗中添加几种不同佐剂,考察其经肌肉免疫后机体的免疫应答情况。结果表明,免疫刺激复合物基质佐剂和左旋咪唑+壳聚糖混合佐剂能有效激发细胞免疫应答和体液免疫应答;左旋咪唑+黄芪多糖混合佐剂能增强疫苗的细胞免疫刺激能力,而对体液免疫无作用;皂角素佐剂未显示明显的免疫增强效果。本试验结果为肌肉注射猪支原体肺炎活疫苗的开发奠定了数据基础。
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| 关 键 词： | 佐剂 活疫苗 猪支原体肺炎 |
| 收稿时间： | 2011-01-28 |
Immune Study of a Intramuscular Injected Live Vaccine against Mycoplasma hyopneumoniae Enhanced by Different Adjuvants |
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| XIONG Qi-yan,FAN Zhi-peng,GAN Yuan,KONG Meng,FENG Zhi-xin,LIU Mao-iun,SHAO Guo-qing.Immune Study of a Intramuscular Injected Live Vaccine against Mycoplasma hyopneumoniae Enhanced by Different Adjuvants[J].China Animal Husbandry & Veterinary Medicine,2011,38(10):163-168. |
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| Authors: | XIONG Qi-yan FAN Zhi-peng GAN Yuan KONG Meng FENG Zhi-xin LIU Mao-iun SHAO Guo-qing |
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| Institution: | 1. Key Laboratory of Animal Diseases Diagnostic and Immunology,Ministry of Agriculture,National Center for Engineering Research of Veterinary Bio-products,Institute of Veterinary Medicine,Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China;2. Graduate College of Shanxi Agricultural University,Taigu 030801, China |
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| Abstract: | To achieve the intramuscular injection of the attenuated live vaccine against Mycoplasma hyopneumoniae,different adjuvants were applied to enhance the immunogenicity of the vaccine.Cellular and humoral immune response was detected after the immunization.The results showed that ISCOM-matrix,as well as the mixture of levamisole and chitosan,effectively increased the proliferation of PBMC and the level of serum IgG antibody.The mixture of levamisole and astragalus polysaccharide only enhanced the cellular immu... |
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| Keywords: | adjuvant live vaccine mycoplasmal pneumonia of swine |
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