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| 家蚕蛹壳聚糖复合海绵止血材料的制备及止血性能测试 | |
| 引用本文： | 陈超,蓝广芊,吴大洋. 家蚕蛹壳聚糖复合海绵止血材料的制备及止血性能测试[J]. 蚕业科学, 2011, 37(6): 1123-1127 |
| 作者姓名： | 陈超 蓝广芊 吴大洋 |
| 作者单位： | 西南大学纺织服装学院,重庆,400716 |
| 基金项目： | 重庆市科技攻关计划项目(No.CSTC,2008AB1005) |
| 摘 要： | 以从家蚕蛹壳中提取的壳聚糖为主要原料,与明胶共混溶解后加入助剂,通过冷冻真空干燥法制备海绵状复合止血材料。采用L16(45)正交试验,探讨复合止血材料中蚕蛹壳聚糖、明胶以及戊二醛、氯化钙和甘油等助剂的含量对体外凝血指数(BCI)的影响。各因素对BCI的影响大小顺序是:蚕蛹壳聚糖>氯化钙>戊二醛>明胶>甘油。优化复合止血材料中各组分的质量分数为:蚕蛹壳聚糖2.5%,明胶3.0%,戊二醛0.005%,氯化钙0.1%,甘油0.05%。对该复合止血材料进行体外凝血测试,并制作家兔耳动脉出血模型进行活体止血效果的试验,结果均表明其具有良好的止血效果,体外凝血指数较医用纱布和明胶海绵极显著下降,对缩短家兔耳动脉止血时间和降低出血量均极显著优于医用纱布和明胶海绵。 |
| 关 键 词： | 家蚕蛹 壳聚糖 止血材料 凝血指数 |
Preparation and Haemostatic Property Test of a Silkworm Pupa-derived Chitosan Composite Sponge Material |
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| CHEN Chao,LAN Guang-Qian,WU Da-Yang. Preparation and Haemostatic Property Test of a Silkworm Pupa-derived Chitosan Composite Sponge Material[J]. Acta Sericologica Sinica, 2011, 37(6): 1123-1127 | |
| Authors: | CHEN Chao LAN Guang-Qian WU Da-Yang |
| Affiliation: | CHEN Chao LAN Guang-Qian WU Da-Yang(College of Textiles & Garments,Southwest University,Chongqing 400716,China) |
| Abstract: | A composite sponge-like haemostatic material was prepared using silkworm pupa-derived chitosan as the major ingredient which was mixed with gelatin and other auxiliary agents by means of freeze vacuum drying.An L16(45) orthogonal experiment was conducted to test the influence of chitosan,gelatin,glutaraldehyde,calcium chloride,and glycerol contents on in vitro blood clotting index(BCI) of the composite haemostatic material.Experimental results showed that the influence of each factor on BCI is in the order ... |
| Keywords: | Silkworm pupa Chitosan Haemostatic material Blood clotting index |
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