H-Y抗原候选基因的研究进展

雄性特异性组织相容性抗原(male specific minor histompatibility antigens,H-Y抗原)是由Y染色体上的基因编码,在雄性动物细胞中普遍表达(包括胚胎和滋养层细胞)。H-Y抗原不仅能引起基因型相同的雌性动物排斥雄性组织,也能导致人白细胞抗原匹配干细胞移植术后出现移植抗宿主性疾病(GVH)。细胞毒性T淋巴细胞检测到几个不同的H-Y抗原表位,这些肽是从胞内蛋白分离出来,由主要组织相容性复合分子结合呈递在细胞表面。H-Y抗原肽与人白细胞抗原Ⅰ类和Ⅱ类分子特异结合参与免疫反应,从而影响移植结果。近年来越来越多的文献报道了H-Y抗原的相关研究,作者主要综述编码H-Y抗原的相关候选基因,并对它在疾病等方面的前景作出了一些展望。

Progress on Candidate Genes for H-Y Antigens

Male specific minor histocomp atibility(H-Y) antigens are encoded by genes on the Y-chromosome.Generally,the minor H-Y antigens are ubiquitously expressed in male cells including fetal and trophoblast cells.It causes rejection of male tissue grafts by genotypically identical female mice and contributes to graft rejection or graft-versus-host(GVH) disease after HLA-identical stem cell transplantation.Cytotoxicity lymphocytic cells detected several distinct H-Y epitopes,and these are probably peptides,derived...