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Territrem and Butyrolactone Derivatives from a Marine-Derived Fungus Aspergillus Terreus
Authors:Xu-Hua Nong  Yi-Fei Wang  Xiao-Yong Zhang  Mu-Ping Zhou  Xin-Ya Xu  Shu-Hua Qi
Affiliation:1CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica/RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301 Guangdong, China; E-Mails: (X.-H.N.); (X.-Y.Z.); (X.-Y.X.);2Jinan University, 601 West Huangpu Road, Guangzhou, 510632 Guangdong, China; E-Mails: (Y.-F.W.); (M.-P.Z.)
Abstract:Seventeen lactones including eight territrem derivatives (1–8) and nine butyrolactone derivatives (9–17) were isolated from a marine-derived fungus Aspergillusterreus SCSGAF0162 under solid-state fermentation of rice. Compounds 1–3 and 9–10 were new, and their structures were elucidated by spectroscopic analysis. The acetylcholinesterase inhibitory activity and antiviral activity of compounds 1–17 were evaluated. Among them, compounds 1 and 2 showed strong inhibitory activity against acetylcholinesterase with IC50 values of 4.2 ± 0.6, 4.5 ± 0.6 nM, respectively. This is the first time it has been reported that 3, 6, 10, 12 had evident antiviral activity towards HSV-1 with IC50 values of 16.4 ± 0.6, 6.34 ± 0.4, 21.8 ± 0.8 and 28.9 ± 0.8 μg·mL−1, respectively. Antifouling bioassay tests showed that compounds 1, 11, 12, 15 had potent antifouling activity with EC50 values of 12.9 ± 0.5, 22.1 ± 0.8, 7.4 ± 0.6, 16.1 ± 0.6 μg·mL−1 toward barnacle Balanus amphitrite larvae, respectively.
Keywords:Aspergillusterreus   anti-acetylcholinesterase   anti-HSV-1   antifouling   butyrolactone derivative   territrem derivative
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