| 不同固体剂型银翘解毒制剂的溶出度考察 |
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| 引用本文： | 万军,贾程程,翟羽佳,闫翠起. 不同固体剂型银翘解毒制剂的溶出度考察[J]. 安徽农业科学, 2011, 39(14): 8341-8342 |
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| 作者姓名： | 万军 贾程程 翟羽佳 闫翠起 |
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| 作者单位： | 西南交通大学生命科学与工程学院; |
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| 基金项目： | 中央高校基本科研业务费专项资金项目(SWJTU09BR220;SWJTU09ZT29) |
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| 摘 要： | [目的]比较8个厂家不同固体剂型银翘解毒片剂、胶囊剂和丸剂的溶出度,为临床用药提供参考。[方法]采用紫外分光光度法测定绿原酸的吸光度值,转篮法测定溶出度,并以威布尔分布模型拟合溶出参数。[结果]8个厂家不同固体剂型中银翘解毒片剂、胶囊剂和丸剂的溶出度、崩解时限均符合2005年版《中国药典》规定,T50与崩解时限无显著相关性（P〉0.05）。[结论]该方法简便、快速、稳定性好、结果准确,可用于药品制剂的质量控制。
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| 关 键 词： | 银翘解毒制剂 溶出度 紫外分光光度法 |
Dissolution Rate of Yinqiao Jiedu Preparation in Different Solid Dosage Forms |
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| WAN Jun et al. Dissolution Rate of Yinqiao Jiedu Preparation in Different Solid Dosage Forms[J]. Journal of Anhui Agricultural Sciences, 2011, 39(14): 8341-8342 |
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| Authors: | WAN Jun et al |
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| Affiliation: | WAN Jun et al(Life Science & Engineering College,Southwest Jiaotong University,Chengdu,Sichuan 610031) |
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| Abstract: | [Objective] The aim was to compare the dissolution rates of Yinqiao Jiedu tablets,capsules and pills from eight manufactures so as to offer reference for clinical medication.[Method] The absorbance of chlorogenic acid was measured by ultraviolet spectrophotometry;the dissolution was determined by rotating basket method,the parameters on stripping curves were fitted by Weibull distribution model.[Result] All the dissolution rates & disintegration time limit of Yinqiao Jiedu tablets,capsules and pills prepara... |
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| Keywords: | Yinqiao Jiedu preparation Dissolution rate Ultraviolet spectrophometry |
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